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Xiangqun Zeng

Headshot - Xiangqun Zeng

Title: Distinguished Professor
Analytical Chemistry
Office: 231 Mathematics and Science Center
Phone: (248)370-2881
E-mail: [email protected]
Research Group Page


B.S. Chengdu University of Science and Technology - 1989
M.S. Beijing Normal University - 1992
Ph.D., State University of New York at Buffalo - 1997

Research Interests

Professor Zeng current research centers on bioanalytical, electroanalytical and electrochemistry at metal electrode interfaces with two active research programs: one focused on bioanalytical chemistry for clinical diagnosis and therapy, and another focused on fundamental and applied electrochemistry for sensors and energy storage device applications. The Zeng lab is interested in the study of fundamental and applied interfacial phenomena, particularly the design and control of molecular characters;and characterizations of the dynamic reactions at electrode interfaces. She has been working on the areas of electrochemistry and interface chemistry at solid electrodes, development of new analytical techniques, chemical and biosensors, and ionic liquids and conductive polymers. Current projects in Zeng lab are: (1) Understanding the interfacial composition, structure and properties of ionic liquids and conductive polymers for sensor and energy storage applications; (2) Applying principles from chemistry and biology for directed assembly or synthesis of thin films of conductive polymers, biological molecules (peptides, proteins and carbohydrates), cells and inorganics on electrode surfaces; (3) Developing miniaturized analysis platforms that combines high performance, chip-scale instrumentation electronics with multi-transduction-mode sensor array devices by collaboration with engineers. The research direction in Zeng lab is motivated by the increasing needs of new sensor technology for a broad range of applications relating to national security, health care, the environment, energy, food safety, and manufacturing. Although new and improved sensor technology will continue to be developed, the most crucial needs in any sensors are the recognition elements at the interface and the fundamental understanding of the molecular recognition events at the interfaces. By collaboration with various scientists and engineers, we have identified new sensor recognition elements (i.e. recombinant antibody, carbohydrate, ionic liquid, biopolymers and cells) and demonstrated their use as chemical and biosensing materials for fabricating new sensor structures with strong potential capabilities including limited size, weight and power consumption by using label free transducers. Furthermore, the fundamental understanding of the interface properties of various chemical and biointerfaces allow us to explore new directions in Lithium ion battery electrolytes, electrocatalysis for fuel cells and solid state fuel cells and new research directions in biomedical research including cancer and infectious diseases.

All current and completed projects in Zeng lab are interdisciplinary in nature (electrochemistry, spectroscopy, material science, bioengineering, biology and medicine) involve using of multiple electrochemical, spectroscopic and microscopic techniques in order to determine the composition, structure and dynamic interfacial properties at electrode interfaces. By combining the results of diverse in situ techniques (electrochemical quartz crystal microbalance (EQCM), rotating ring disk electrodes (RRDE), cyclic voltammetry (CV), electrochemical impedance spectroscopy, surface plasmon resonance (SPR), ellipsometry, ATR and RA FT-IR, scanning probe techniques (i.e. atomic force microscope (AFM) and scanning tunneling microscope (STM)), fundamental understanding of the electrode interface properties can be obtained. This in turn enables the development of new electrode surfaces in which interesting properties can be tailored by incorporating appropriate inorganic, organic and biological constituents for a broad range of applications from electrochemical energy conversion (fuel cell, batteries and electrocatalysis) to chemical sensors and biosensors for clinical diagnosis, environmental monitoring and biomedical research.

Professor Xiangqun Zeng completed her Ph.D.(in three years) and postdoc (one year) at State University of New York at Buffalo (SUNY Buffalo) at Professor Stanley Bruckenstein’s laboratory. During her Ph.D. and Postdoc study, she also worked closely with Professor Robert Hillman at Leicester University in UK (ex-president of International Society of Electrochemistry) and Dr. Joseph Gardella at SUNY Buffalo. Her academic grandfather Dr. Izaak Kolthoff is regarded as the father of Analytical Chemistry (http://en.wikipedia.org/wiki/Izaak_Kolthoff). She has obtained extramural funding totaling over $6 million from National Institute of Health (2013 R01, 2002 R21/R33 and 2009 R21), National Institute of Occupational and Safety Health (2009 R21 and 2010 R01), Office of Naval Research (2010), Michigan Universities Commercialization Initiative/Michigan Initiative for Innovation and Entrepreneurship (2005/2006/2007/ 2012), ACS PRF (2001) and Cottrell College Science Award from Research Corporation (2000).  She has published ~ seventy high quality peer reviewed journal papers, held 6 patents, written three book chapters and given over 100 invited seminars.  Dr. Zeng has supervised 13 postdoc researchers, 10 Ph.D. students (5 Ph.D. thesis and 5 visiting shared Ph.D. from other institutions), 18 M.S. students (8 M.S. thesis at Oakland and one M.S. thesis from another institution), 20 undergraduate students and four high school student research projects. She also hosted and supervised six visiting professors for their sabbatical researches.  Professor Zeng is a regular NIH, NSF and DOD grant reviewer and has served on more than 30 federal grant review panels. Additionally, she has served as a Conference Session Co-Chair on Sensors and Actuators for the ACS National Meeting in 2008; as a Section Chair for Symposium 3- Electroanalysis and Electrochemical Sensors at the 60th Annual Meeting of the International Society of Electrochemistry in 2009; and was an invited keynote speaker and also served as session chair for the Symposium on “Electroanalytical Chemistry” for the 14 th and 15 th  Beijing Conference and Exhibition of Instrumental Analysis (BCEIA 2011/2013). Professor Zeng received the Oakland University Young Investigator Research Excellence Award in 2005 and Academic Excellence Recognition Awards in 2011 and 2012. 

Selected Publications

Yijun Tang, Xiangqun Zeng*,  Poly(Vinyl Ferrocene) Redox Behavior in Ionic LiquidsJ. Electrochem. Soc. 2008, 155(55), F82-F90.

Xiaoxia Jin, Lei Yu, Xiangqun Zeng*,  Enhancing the Sensitivity of Ionic Liquid Sensors for Methane Detection with Polyaniline TemplateSensors & Actuators B. Chemical, In press.

Xiaoming Wu, Zhihong Shen, Xiangqun Zeng, Shenhui Lian, Michael Palmer and Zhongwu Guo*,  Synthesis and Biological Evaluation of Sperm CD52 GPI Anchor and Related Derivatives as Binding Receptors for Poring-forming CAMP FactorCarbohydrate Research, in press.

Richard West, Xiangqun Zeng*,  Controlled Electrochemical Synthesis of Polypyrrole Nanoparticle Thin Film and Its Redox Transition to a Highly Conductive and Stable Polypyrrole VariantLangmuir, In revision.

Zhihong Shen; Heping Yan; Ying Zhang; Raymond Mernaugh; Xiangqun Zeng*,  Engineering peptide linker for scFv immunosensors, Anal. Chem. 2008, 80(6), 1910-1917.

Lei Yu, Mingchuan Huang , Peng G. Wang, and Xiangqun Zeng*,  Cross-linked Surface-Grafted Glycopolymer for Multivalent Recognition of LectinAnal. Chem. 2007, 79(23), 8979-8986.

Mingchuan Huang , Zhihong Shen , Yalong Zhang , Xiangqun Zeng* , Peng George Wang*,  Alkanethiol Containing Glycopolymers: A Tool for the Detection of Lectin BindingBioorganic and Medicinal Chemistry Letters, 2007, 17, 5379-5383.

Zhihong Shen, Mingchuan Huang, Caide Xiao, Yun Zhang, Xiangqun Zeng*, Peng G. Wang*,  Non-label QCM Biosensor for Bacterial Detection using Carbohydrate and Lectin RecognitionsAnal. Chem. 2007, 79(6), 2312-2319.

Zhihong Shen, Heping Yan, Paul Fritz, Ray Mernuagh, Xiangqun Zeng*,  Recombinant Antibody Piezo Immunosensors for the Detection of CYP1B1 (Cytochrome P450 1B1)Anal. Chem. 2007, 79(4), 1283-1289.

Xiaoxia Jin, Lei Yu, Deigo Garcia, Rex X. Ren, Xiangqun Zeng*,  Ionic Liquid High Temperature Gas Sensor Array, Anal. Chem. 2006, 78, 6980-6989.

Tang Y., Mernaugh R., Zeng X.*,  Non-Regeneration Protocol for Surface Plasmon Resonance: Study of High-Affinity Interaction with High-Density BiosensorsAnal. Chem. 2006, 78(6), 1841-1848.

Zhang Y., Luo S., Tang Y., Yu L., Hou K., Cheng J., Zeng X.* , Wang P. G.*,  Carbohydrate-Protein Interactions by “Clicked” Carbohydrate Self-Assembled MonolayersAnal. Chem. 2006, 78(6), 2001-2008.

Zhihong Shen, Ray Mernaugh, Heping Yan, Lei Yu, Ying Zhang, Xiangqun Zeng*,  Engineered Recombinant scFv for ImmunosensorsAnal. Chem. 2005, 77(21); 6834-6842.

Lei Yu, Meghana Sathe, Xiangqun Zeng*,  EQCM Study of the Redox Processes of Polyvinylferrocene Film in L-Glutamine SolutionJ. Electrochem. Soc., 2005, 152(11), E357-E363.

Hou K., Yu L., Severson W. M., Zeng X.*,  Adsorption of 1,10-phenanthroline within Dodecylthiol Monolayer–An Approach to a Switchable Electrode SurfaceJ. Phys. Chem. B., 109(19); 9527-9531, 2005.

Yu L., Diego G., Ren X. R., Zeng X.*,  Ionic Liquid High Temperature Gas SensorsChemical Communication, 2005, 2277-2279.

Shen Z., Stryker G., Mernaugh R., Yu L., Yan H., Zeng X.*,  Single-chain Fragment Variable (scFv) Antibody Piezo ImmunosensorsAnalytical ChemistryVol. 77, p797-805, 2005.

Sathe M., Yu L., Mo Y., Zeng X.*,  Doping and Undoping of OH- During the Redox Processes of PolyvinylferroceneJournal of Electrochemistry SocietyVol. 152, No. 3, E94-E97, 2005.

Zhang Y., Telyatnikov V., Sathe M., Zeng X*., Wang P.*,  Studying the interaction of alpha-Gal carbohydrate antigen and proteins by Quartz-Crystal Microbalance (QCM)Journal of American Chemical Society CommunicationVol. 125, No. 31, 9292-9293 (2003).

Zeng X., Hatton R.,  EQCM study of adsorption of bipyridine on Au polycrystalline electrode using UPD Pb as a probeElectrochimica Acta, The QCM in Electrochemistry,  Vol. 45, 3629-3638 (2000).

Zeng X., Bruckenstein S.,  Study of Underpotential Deposition and Adsorption of Lead on Polycrystalline Gold Electrode. Part I. XPS and TOF-SIMS Investigation in Sodium Chloride ElectrolyteJournal of the Electrochemical SocietyVol.146, 2549-2554 (1999).

Zeng X., Bruckenstein S.,  Study of Underpotential Deposition and Adsorption of Lead on Polycrystalline Gold Electrode. Part II. Electrochemical Investigation in Sodium Chloride and Sodium Perchloride Electrolyte, Journal of the Electrochemical SocietyVol.146, 2555-2561 (1999).

Zeng X., Bruckenstein S.,  Polycrystalline Gold Electrode Redox Behavior in an Ammoniacal Electrolyte. Part I. A Parallel RRDE, EQCM, XPS and TOF-SIMS Study of Supporting Electrolyte PhenomenaJournal of Electroanalytical ChemistryVol.461, 131-142 (1999).

Zeng X., Bruckenstein S.,  Polycrystalline Gold Electrode Redox Behavior in an Ammoniacal Electrolyte. Part II. A Parallel RRDE, EQCM, and TOF-SIMS Study of Copper Underpotential DepositionJournal of Electroanalytical ChemistryVol. 461, 143-153 (1999).

Zeng X., Moon S., Bruckenstein S., Hillman R. A.  XPS Study of Counterion Incorporation at Poly(vinylferrocene), Analytical ChemistryVol 70, 2613-2617 (1998).

Zeng X., Prasad S., Bruckenstein S.  XPS and TOF-SIMS Studies of Underpotential Deposition of Hg on Gold ElectrodeLangmuirVol. 14, 2535-2540 (1998).

Department of Chemistry

Mathematics and Science Center, Room 260
146 Library Drive
Rochester, , MI 48309-4479
(location map)
(248) 370-2320
fax: 370-2321