Mathematics and Science Center
118 Library Drive
Rochester, MI 48309-4479
(location map)

The Institute for Stem Cell and Regenerative Medicine, close up of cells that have been dyed blue


About the ISCRM

The Institute for Stem Cell and Regenerative Medicine (ISCRM) is a bi-institutional center composed of investigators from Beaumont Health System and Oakland University. Building on more than 10 years of history of stem cell research at OU and William Beaumont, the ISCRM  was created in 2010 with a small contribution from both institutions with a mission to utilize human stem cell, tissue engineering and regenerative technologies to treat human injuries, disease and disorders.

The ISCRM promotes and provides a comprehensive and coordinated "bench to bedside" approach to regenerative medicine, including basic biomedical and clinical research, tissue engineering and regenerative approaches, and the development and administration of stem cell-based therapies to patients.

The vision of the ISCRM is to rapidly translate cutting-edge stem cell and tissue engineering research into the clinic and for commercial applications for treating human diseases and disorders. 

Recent Publications  

McKee C, Beeravolu N, Brown C, Perez-Cruet M, Chaudhry GR. 2019. Mesenchymal stem cells transplanted with self-assembling scaffolds differentiated to regenerate nucleus pulposus in an ex vivo model of degenerative disc disease. Applied Materials Today. (Under Revision).

Brown C, Mckee C, Bakshi S, Walker K, Hakman E, Halassy S, Svinarich D, Dodds R, Govind C, Chaudhry GR. 2019. Mesenchymal Stem Cells: Sources, Therapeutic Potential, and Challenges. doi: 10.1002/term.2914.

Bakshi S, Mckee C, Walker K, Brown C, Chaudhry GR. 2018. Toxicity of JQ1 in neuronal derivatives of human umbilical cord mesenchymal stem cell. Oncotarget. 9 (73):33853-33864. doi:10.18632/oncotarget.26127.

McKee C, Beeravolu N, Bakshi S, Thibodeau B, Wilson G, Perez-Cruet M, Chaudhry GR. 2018. Cytotoxicity of radiocontrast dyes in human umbilical cord mesenchymal stem cells.Toxicology and Applied Pharmacology. 349: 72-82. doi: 10.1016/j.taap.2018.04.032.

Perez-Cruet M, Beeravolu N, McKee C, Brougham J, Khan I, Bakshi S, Chaudhry GR. 2018. Potential of human NP-like cells derived from umbilical cord to treat degenerative disc disease. Neurosurgery. doi: 10.1093/neuros/nyy012.

McKee C, Chaudhry GR. 2017. Advances and challenges in stem cell culture. Colloids and Surfaces B: Biointerfaces. 159: 62-77.

McKee C, Yao D, Chaudhry GR. 2017. Chondrogenic differentiation of embryonic stem cells using mechanotransductive 3-D PDMS scaffolds. Stem Cell and Transnational Investigation. 4:e1536. doi: 10.14800/scti.1536.

Beeravolu, N, C. McKee, G.R. Chaudhry. 2017. Mechanism of arsenite toxicity in embryonic stem cells. Journal of Applied Toxicology.  37(10): 1151-1161. doi: 10.1002/jat.3469.

McKee, C, Hong, Y, Yao, D, Chaudhry, GR. 2017. Compression induced chondrogenic differentiation of embryonic stem cells in 3-D PDMS scaffolds. Tissue Engineering Part A. 23(9-10): 426-435. doi: 10.1089/ten.TEA.2016.0376.

Beeravolu N, Brougham J, Khan I, McKee C, Perez-Cruet M, Chaudhry GR. 2017. Human Umbilical Cord Derivatives Regenerate Intervertebral Disc. Journal of Tissue Engineering and Regenerative Medicine. 12(1): 579-591. doi: 10.1002/term.2330.

Beeravolu N, McKee C, Alamri A, Mikhael S, Brown C, Perez-Cruet M, Chaudhry GR. 2017. Isolation and characterization of mesenchymal stem cells from different regions of the human umbilical cord. Journal of Visualized Experiments. (122): e55224. doi: 10.3791/55224.

Mikhael S, Beeravolu N, Chaudhry GR. 2016. Umbilical cord derivatives for intervertebral disc regeneration: advances and challenges. Editorial. Cell and Gene Therapy Insights. 2(6): 629-634. doi: 10.18609/cgti.2016.076.

Beeravolu N, Khan I, McKee C, Dinda S, Thibodeau B, Wilson G, Perez-Cruet M, Bahado-Singh R, Chaudhry GR. 2016. Isolation and comparative analysis of potential stem cells from different regions of human umbilical cord. Stem Cell Research. 16: 696-711. doi: 10.1016/j.scr.2016.04.010.

Alghamdi S, Khan I, Beeravolu N, Mckee C, Thibodeau B, Wilson G, Chaudhry GR. 2016. BET protein inhibitor JQ1 inhibits growth and modulates WNT signaling in mesenchymal stem cells. Stem Cell Research and Therapy. 7:22. doi: 10.1186/s13287-016-0278-3.