ISCRM

Mathematics and Science Center
118 Library Drive
Rochester, MI 48309-4479
(location map)

Research, two women wearing white coats and blue gloves in a lab holding test tubes

Research

Research Programs
OU-WB Institute for Stem Cell and Regenerative Medicine 
 
Research Program
Stem Cell Biology - Cancer - Tissue Bioengineering - Regenerative Medicine - Therapeutics

The ISCRM promotes research involving molecular mechanisms that maintain stemness and induce differentiation in stem cells (SCs). SCs provide a renewable resource for tissue engineering and cell therapy. Embryonic stem cells (ESCs) have the greatest potential to self-renew and capacity to differentiate. Cord blood stem cells (CBSCs) and adult stem cells (ASCs) are less potent but are more desirable sources for therapeutic applications. The following are potential areas of stem cell research:


Regulation of stemness and differentiation of ESCs, CBSCs and ASCs
  •       Neurogenesis
  •       Osteogenesis
  •       Chondrogenesis
  •             Adipogenesis
  •       Myogenesis

Umbilical cord stem cells

  •       Future treatments for developmental and early childhood diseases, including Leukemia, Sickle-cell       anemia, and various immunodeficiencies
  •       Use of CBSCs to investigate inherited disorders and disease processes

Induced pluripotent stem (iPS) cell generation, stability, and differentiation

  •       Normal skin cells
  •       Reverse engineering disease pathways

Tissue engineering using human stem cells

  •       Bone and cartilage tissues/structures
  •       Nucleus pulposis in degenerated intervertebral disc
  •       Neural tissues damaged by spinal cord injuries
  •       Fabrication of scaffolds and devices for stem cell collection and tissue regeneration

Restoration of damaged tissue/organ function

  •       Regeneration of pelvic nerve to restore detrusor muscle function in SCIs
  •       Treatment of retinal degeneration using stem cell therapy
  •       Cardiovascular injury and repair
  •       Stem cells for wound healing

Treatment of developmental and age-related degenerative diseases using stem cell therapy

  •       Leukemia
  •       Incontinence
  •       Multiple sclerosis
  •       Parkinson’s disease
  •       Alzheimer’s disease
  •       Diabetes
  •       ALS

Drug discovery and development

  •       miRNA based drugs

Toxicological studies

  •       Development of the NET (New Embryotoxicity) assay for screening drugs and chemicals
  •       Mechanisms of DNA damage and repair in SCs
Research Projects

Research Projects

  1. Collection and characterization of umbilical cord blood stem cells for potential therapeutic uses
  2. Intervertebral disc regeneration using cord blood derived stem cells
  3. Role of mononuclear cells in repair and regeneration
  4. Self-assembling scaffolds for embryonic stem cell (ESC) culture, storage and shipping
  5. Stem cell therapy for treatment of macular degeneration
  6. Effect of estrogen and progesterone on embryonic cell development and differentiation
  7. Potential and feasibility of stem cell therapy for treatment of Parkinson’s disease
  8. Neural differentiation of stem cells into oligodendrocytes for treatment of multiple sclerosis (MS)
  9. Effect of heavy metals on the developmental and differentiation processes 
  10. Dopaminergic differentiation of cord blood derived stem cells
  11. Differentiation of ESCs into islet cells; potential cell therapy for the treatment of diabetes mellitus
  12. Bone and cartilage tissue bioengineering for TMJ reconstruction
  13. Stem cells for wound healing
  14. Pharmacological and toxicological studies using ESCs as a model for early development and differentiation
  15. Human chip for pharmacological and drug development studies
  16. Peripheral and cord blood derived HSC propagation for cell therapy
  17. Neural mapping of brain and nerve regeneration using ESCs derivatives
  18. iPSCs for reverse engineering disease pathways