andrew-f-x-goldberg


Associate Professor of Biomedical Sciences
359 Dodge Hall of Engineering
(248) 370-2393
goldberg@oakland.edu


Education

B.S. from Binghamton University

1985, Binghamton, New York, United States

Biochemistry/Philosophy

Ph.D. from Brandeis University

1992, Waltham, Massachusetts, United States

Biochemistry

Postdoctoral from University of British Columbia

1997, Vancouver, British Columbia, Canada

Photoreceptor structure

Postdoctoral from University of Washington

1998, Seattle, Washington, United States

Photoreceptor function

Research

Retinal degenerative diseases currently cause vision loss and blindness in more than 2 million persons in the US alone, and this number will grow significantly in the coming decade.  Although many instances of disease are caused by defects in the light-sensitive rod and cone photoreceptors, the fundamental biology of these critical neurons in not well understood, and halting or reversing the pathological progression of vision loss remains an unrealized dream.  The laboratory's efforts are focused on understanding and combating inherited forms of retinal disease caused by defects in rods and cone cell structure.  Ongoing studies are detailing the normal architecture of these specialized neurons, and the distinctive ways that particular instances of genetic disease compromise photoreceptor structure.  These studies are accomplished using a wide variety of biochemical, biophysical, and molecular genetic techniques in vitro, in cellulo, and in vivo.  Additional information is available on the Goldberg Laboratory Web page.

Funding

National Science Foundation

The Grass Foundation

National Eye Institute

E. Matilda Zeigler Foundation

Research Excellence Fund (Oakland University)

Mid-West Eyebanks

Memberships

Association for Research in Vision and Ophthalmology (ARVO)

American Society for Biochemistry and Molecular Biology (ASBMB)

Society for Neuroscience (SfN)

Biophysical Society

Recent Publications

  1. Khattree N, Ritter LM, Goldberg AFX.  Membrane curvature generation by a C-terminal amphipathic helix in peripherin-2/rds, a tetraspanin required for photoreceptor sensory cilium morphogenesis.  J. Cell Sci., 126, 4659-4670 (2013).  

  2. Goldberg AFX.  Essential tetraspanin functions in the vertebrate retina.  In: Berditchevski and Rubenstein (Eds.), Tetraspanins: current concepts and future challenges.  Vol. 9, Springer Inc., Chapter 13, p321-43. (2013).     

  3. Sharma YV, Cojocaru RI, Ritter LM, Khattree N, Brooks M, Scott A, Swaroop A, Goldberg AFX.  Protective gene expression changes elicited by an inherited defect in photoreceptor structure.  PLoS One, 7, e31371 (2012). 

  4. Peachey NS, Ray TA, Florijn R, Rowe LB, Sjoerdsma T, Contreras-Alcantara S, Baba K, Tosini G, Pozdeyev N, Iuvone PM, Bojang P Jr, Pearring JN, Simonsz HJ, van Genderen M, Birch DG, Traboulsi EI, Dorfman A, Lopez I, Ren H, Goldberg AFX, Nishina PM, Lachapelle P, McCall MA, Koenekoop RK, Bergen AA, Kamermans M, Gregg RG.  GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal-recessive complete congenital stationary night blindness.  Am. J. Hum. Genet., 90, 331-339 (2012).

  5. Ku CA, Chiodo VA, Boye SL, Goldberg AFX, Li T, Hauswirth WW, Ramamurthy V.  Gene therapy using self-complementary Y733F capsid mutant AAV2/8 restores vision in a model of early onset Leber congenital amaurosis.  Hum. Mol. Genet., 20, 4569-4581 (2011).