Updates & Announcements

Exempt rDNA Form: 

A new form has been implemented to assist the IBC and applicants in determining if their experiments are exempt. The form is located in the "Overview" tab to the left or you can directly access the form by clicking on Exempt rDNA form

CRISPR Risk Assessment:

Over the past year there has been a significant number of IBC applications utilizing the powerful gene-editing technology referred to as “CRISPR”. The IBC wants to remind investigators that there are reporting requirements and risks to consider when working with recombinant DNA molecules. All rDNA experiments must be registered with Oakland University’s IBC (exempt or not). Non-exempt experiments must be approved by a convened IBC.

CRISPR technology has a number of risks that the IBC and investigators must consider when approving a project, but there are two applications where the technology poses significant risks.

  1. CRISPR experiments where the guide RNA can target a human gene, whether it is intentional or as an off-target event.
  2. “Gene Drive” experiments which increase the spread of genetic elements in a population much quicker than what occurs naturally. Experiments where there is a risk of creating a gene drive system must be carefully evaluated to prevent unintended ecological effects.

For more information on evaluating the risks of your rDNA experiments please click on the Recombinant DNA link on the left column of this page. If you require assistance in evaluating any of the risks involved in your research, please contact Laboratory Compliance Manager, Domenic Luongo at .