Department of Biological Sciences
Dodge Hall Rm 375
118 Library Dr
Rochester, MI 48309-4479
(map)
(248) 370-3550
fax: (248) 370-4225

Blumer Schuette

Sara Blumer-Schuette
Assistant Professor, Ph.D.
331 MSC
248-370-3168
Lab location: 330 MSC
Lab phone: (248) 370-4903
blumerschuette@oakland.edu

Blumer-Schuette Lab Website

Courses:

  • BIO 111 Biology I
  • BIIO 319 Microbiology
  • BIO 441/541 Microbial Biotechnology

 

Microbial Physiology and Genomics

Non-model environmental microorganisms are promising reservoirs of unique metabolic pathways that can be harnessed to replace traditional synthetic chemistry. Professor Blumer-Schuette’s research interests include microbial physiology and genomics of non-model microorganisms living at the extremes of life. Current projects include unraveling mechanisms used by extremophilic microbes to interact with substrates that they require as an energy source. Given the intense competition in microbial biospheres, the ability to efficiently harness energy sources, be they organic or inorganic, is crucial for microbes. Implications for understanding these mechanisms range from outlining how microbial attachment mechanisms have functionally evolved, to the environmental implications of these mechanisms and identifying targets for rational design of commercially relevant microbes. Other research interests include characterizing transport systems used to secrete large (some over 200 kDa) enzymes by monoderm bacteria, and how to optimize secretion efficiency of these systems.  In the Blumer-Schuette lab, students can expect to use a combination of anaerobic and aerobic microbiology, functional genomics, microbial genetics and biochemistry in their research projects.

Selected Publications:

Blumer-Schuette, S.E.; Alahuhta, M.; Conway, J.M.; Lee, L.L.; Zurawski, J.V.; Giannone, R.J.; Hettich, R.L.; Lunin, V.V.; Himmel, M.E.; Kelly, R.M. “Discrete and structurally unique proteins (tāpirins) mediate attachment of extremely thermophilic Caldicellulosiruptor species to cellulose.” Journal of Biological Chemistry in press.

Blumer‐Schuette, S.E.; Brown, S.D.; Sander, K.B.; Bayer, E.A.; Kataeva, I.; Zurawski, J.V.; Conway, J.M.; Adams, M.W.W; Kelly, R. M. "Thermophilic lignocellulose deconstruction." FEMS Microbiology Reviews 38: 393-448, 2014.

Frock, A.D.; Montero, C.I.; Blumer-Schuette, S.E.; Kelly, R. M. "Stationary phase and nutrient levels trigger transcription of a genomic locus containing a novel peptide (TM1316) in the hyperthermophilic bacterium Thermotoga maritima." Applied and Environmental Microbiology 79: 6637-6646, 2013.

Blumer-Schuette, S.E.; Giannone, R.J; Zurawski, J.V.; Ozdemir, I.; Ma, Q.; Yin, Y.; Xu, Y.; Kataeva, I.; Poole II, F.L.; Adams, M.W.W.; Hamilton-Brehm, S.D.; Elkins, J.E.; Larimer, F.W.; Land, M.L.; Hauser, L.J.; Cottingham, R.W.; Hettich, R.L.; Kelly, R.M. "Caldicellulosiruptor core and pangenomes reveal determinants for noncellulosomal thermophilic deconstruction of plant biomass." Journal of Bacteriology 194: 4015-4028, 2012.

Blumer-Schuette, S.E.; Lewis, D.L.; Kelly, R.M. “ Phylogenetic, microbiological, and glycoside hydrolase diversities within the extremely thermophilic, plant biomass-degrading genus Caldicellulosiruptor.” Applied and Environmental Microbiology, 76: 8084-8092, 2010.