Monday, October 8, 2012
Graduate student Shamil Hadi to present short course in IraqGraduate student Shamil Hadi, in the Computer Science and Informatics PhD program, was invited to the University of
Baghdad, Karbala University, Kufa University, and Al Nahrain
University, all in Iraq, to teach a short course in The Theory and
Applications of Dynamic Causal Modeling (DCM). Hadi works with CBR member Mohammad-Reza Siadat. An outline of
his course is given below.
“Estimating effective connectivity in human negative emotional network
and inferring the best causal model reveals potentially important
differences between subjects with 5-HTTLRP long- and short-allele. We
estimate effective connectivity among four brain regions that are
activated during the processing of facial affect, e.g., fear: left and
right amygdale (L and R, respectively), caudal supragenual and rostral
subgenual portions of anterior cingulate cortex (rACC and cACC,
respectively). Dynamic causal modeling is used to make inferences
about effective connectivity. Bayesian model selection is also used
for finding the best model from a set of plausible alternative models.
The stimuli paradigm presents fearful facial expressions to a set of
37 subjects who have either two copies of the 5-HTTLRP long-allele or
one copy of the 5-HTTLRP short-allele carriers (15 subjects of
long-allele and 22 subjects of short-allele). Our results revealed
that a fully connected network with no modulated connection was the
winning model for long-allele whereas a fully connected network with
two modulated connections was the winning model for short-allele
individuals. The left to right amygdale (L-R) connections were
significantly different between long- and short-allele (p < 0.0194).
Modulating factor on L-R was found nonzero (p < .05). In conclusion,
this study has shown significant differences between the two groups
(long- and short-allele) during processing of negative emotions.
Further, it has furnished an important role for modulatory input and
left amygdala as discriminatory factors between the two groups.”