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Xiangqun Zeng

Xiangqun Zeng

Title: Professor
Analytical Chemistry
Office: 231 Science and Engineering Building
Phone: (248)370-2881
Research Group Page


B.S. Chengdu University of Science and Technology 
M.S. Beijing Normal University 
Ph.D., State University of New York at Buffalo

Research Interests

Professor Zeng's research interests are electroanalytical and surface chemistry at solid electrodes; development of new analytical techniques, chemical and biosensors; hydrodynamic voltammetry, electroactive polymers. The principal techniques are: electrochemical quartz crystal microbalance (EQCM), rotating ring disk electrodes (RRDE), cyclic voltammetry (CV), electrochemical impedance spectroscopy, Biacore surface plasmon resonance (SPR), reflectance adsorption FT-IR, scanning probe techniques (i.e. atomic force microscope (AFM)) and scanning tunneling microscope (STM)) and Network Impedance Analyzer.

Current research focuses on developing piezobiosensors and electrochemical sensors for detection in complex environmental and clinical samples by combining excellent sensitivity of electrochemical and mass sensing with the superb selectivity of biological recognition processes (e.g. protein-protein interactions, DNA-protein interactions, Carbohydrate-protein interactions). Improvements in the affinity, specificity, sensitivity and selectivity and mass production of the molecular recognition elements are pursued by collaboration with biologists, bioorganic chemists and material chemists at Oakland and other universities.

Other projects in Professor Zeng’s research group are: (1) development of analytical applications using ionic liquids; (2) studying solid-liquid electrochemical Interfacial phenomena. i.e., the mechanisms of solvent transfer and ion transfer processes of conductive polymers and their effect at polymer microscopic structure during the redox switching. It is expected that such fundamental study will lead to development of new electrode surfaces in which interesting properties can be tailored by incorporating appropriate choosing pair of inorganic, organic and biological constituents.

Selected Publications

Yijun Tang, Xiangqun Zeng*, Poly(Vinyl Ferrocene) Redox Behavior in Ionic LiquidsJ. Electrochem. Soc. 2008, 155(55), F82-F90.

Xiaoxia Jin, Lei Yu, Xiangqun Zeng*, Enhancing the Sensitivity of Ionic Liquid Sensors for Methane Detection with Polyaniline TemplateSensors & Actuators B. Chemical, In press.

Xiaoming Wu, Zhihong Shen, Xiangqun Zeng, Shenhui Lian, Michael Palmer and Zhongwu Guo*, Synthesis and Biological Evaluation of Sperm CD52 GPI Anchor and Related Derivatives as Binding Receptors for Poring-forming CAMP FactorCarbohydrate Research, in press.

Richard West, Xiangqun Zeng*, Controlled Electrochemical Synthesis of Polypyrrole Nanoparticle Thin Film and Its Redox Transition to a Highly Conductive and Stable Polypyrrole VariantLangmuir, In revision.

Zhihong Shen; Heping Yan; Ying Zhang; Raymond Mernaugh; Xiangqun Zeng*, Engineering peptide linker for scFv immunosensors, Anal. Chem. 2008, 80(6), 1910-1917.

Lei Yu, Mingchuan Huang , Peng G. Wang, and Xiangqun Zeng*, Cross-linked Surface-Grafted Glycopolymer for Multivalent Recognition of LectinAnal. Chem. 2007, 79(23), 8979-8986.

Mingchuan Huang , Zhihong Shen , Yalong Zhang , Xiangqun Zeng* , Peng George Wang*, Alkanethiol Containing Glycopolymers: A Tool for the Detection of Lectin BindingBioorganic and Medicinal Chemistry Letters, 2007, 17, 5379-5383.

Zhihong Shen, Mingchuan Huang, Caide Xiao, Yun Zhang, Xiangqun Zeng*, Peng G. Wang*, Non-label QCM Biosensor for Bacterial Detection using Carbohydrate and Lectin RecognitionsAnal. Chem. 2007, 79(6), 2312-2319.

Zhihong Shen, Heping Yan, Paul Fritz, Ray Mernuagh, Xiangqun Zeng*, Recombinant Antibody Piezoimmunosensors for the Detection of CYP1B1 (Cytochrome P450 1B1)Anal. Chem. 2007, 79(4), 1283-1289.

Xiaoxia Jin, Lei Yu, Deigo Garcia, Rex X. Ren, Xiangqun Zeng*, Ionic Liquid High Temperature Gas Sensor Array,Anal. Chem. 2006, 78, 6980-6989.

Tang Y., Mernaugh R., Zeng X.*, Non-Regeneration Protocol for Surface Plasmon Resonance: Study of High-Affinity Interaction with High-Density BiosensorsAnal. Chem. 2006, 78(6), 1841-1848.

Zhang Y., Luo S., Tang Y., Yu L., Hou K., Cheng J., Zeng X.* , Wang P. G.*, Carbohydrate-Protein Interactions by “Clicked” Carbohydrate Self-Assembled MonolayersAnal. Chem. 2006, 78(6), 2001-2008.

Zhihong Shen, Ray Mernaugh, Heping Yan, Lei Yu, Ying Zhang, Xiangqun Zeng*, Engineered Recombinant ScFv for ImmunosensorsAnal. Chem. 2005, 77(21); 6834-6842.

Lei Yu, Meghana Sathe, Xiangqun Zeng*, EQCM Study of the Redox Processes of Polyvinylferrocene Film in L-Glutamine SolutionJ. Electrochem. Soc., 2005, 152(11), E357-E363.

Hou K., Yu L., Severson W. M., Zeng X.*, Adsorption of 1,10-phenanthroline within Dodecylthiol Monolayer–An Approach to a Switchable Electrode SurfaceJ. Phys. Chem. B., 109(19); 9527-9531, 2005.

Yu L., Diego G., Ren X. R., Zeng X.*, Ionic Liquid High Temperature Gas SensorsChemical Communication, 2005, 2277-2279.

Shen Z., Stryker G., Mernaugh R., Yu L., Yan H., Zeng X.*, Single-chain Fragment Variable (scFv) Antibody PiezoimmunosensorsAnalytical ChemistryVol. 77, p797-805, 2005.

Sathe M., Yu L., Mo Y., Zeng X.*, Doping and Undoping of OH- During the Redox Processes of PolyvinylferroceneJournal of Electrochemistry SocietyVol. 152, No. 3, E94-E97, 2005.

Zhang Y., Telyatnikov V., Sathe M., Zeng X*., Wang P.*, Studying the interaction of alpha-Gal carbohydrate antigen and proteins by Quartz-Crystal Microbalance (QCM)Journal of American Chemical Society CommunicationVol. 125, No. 31, 9292-9293 (2003).

Zeng X., Hatton R., EQCM study of adsorption of bipyridine on Au polycrystalline electrode using UPD Pb as a probeElectrochimica Acta, The QCM in Electrochemistry, Vol. 45, 3629-3638 (2000).

Zeng X., Bruckenstein S., Study of Underpotential Deposition and Adsorption of Lead on Polycrystalline Gold Electrode. Part I. XPS and TOF-SIMS Investigation in Sodium Chloride ElectrolyteJournal of the Electrochemical SocietyVol.146, 2549-2554 (1999).

Zeng X., Bruckenstein S., Study of Underpotential Deposition and Adsorption of Lead on Polycrystalline Gold Electrode. Part II. Electrochemical Investigation in Sodium Chloride and Sodium Perchloride Electrolyte,Journal of the Electrochemical SocietyVol.146, 2555-2561 (1999).

Zeng X., Bruckenstein S., Polycrystalline Gold Electrode Redox Behavior in an Ammoniacal Electrolyte. Part I. A Parallel RRDE, EQCM, XPS and TOF-SIMS Study of Supporting Electrolyte PhenomenaJournal of Electroanalytical ChemistryVol.461, 131-142 (1999).

Zeng X., Bruckenstein S., Polycrystalline Gold Electrode Redox Behavior in an Ammoniacal Electrolyte. Part II. A Parallel RRDE, EQCM, and TOF-SIMS Study of Copper Underpotential DepositionJournal of Electroanalytical ChemistryVol. 461, 143-153 (1999).

Zeng X., Moon S., Bruckenstein S., Hillman R. A. XPS Study of Counterion Incorporation at Poly(vinylferrocene),Analytical ChemistryVol 70, 2613-2617 (1998).

Zeng X., Prasad S., Bruckenstein S. XPS and TOF-SIMS Studies of Underpotential Deposition of Hg on Gold ElectrodeLangmuirVol. 14, 2535-2540 (1998).