Robert Craig Taylor
Title: Professor Emeritus
Ph.D., Princeton University
Professor Taylor's research interests are concerned with the synthesis, characterization, and potential chemotherapeutic activity of new complexes of the platinum group metals (Pd, Pt, Rh, and Ir) with special emphasis on platinum(II) and platinum(IV) complexes. During the past few years his group has been investigating the square planar Pt(II) and octahedral Pt(IV) complexes containing various organonitriles (RCN) and the reactions of these coordinated nitriles with various nucleophiles leading to coordinated iminoethers,amidates,amidines, and oxazolines.These conversions at a Pt(II) or Pt(IV) center lead to some interesting stereochemistries. In addition, a number of the iminoether derivatives of Pt(II) have been shown by others to exhibit antitumor activity. What is also unusual above these complexes is that the trans-isomers are more antitumor active than the cis-isomers, a finding that is contrary to all previously known structure-activity relationships for platinum(II) antitumor agents.At present, nothing is known about the biological significance of the corresponding Pt(IV) complexes containing these same ligands.
The second area of research is closely tied in with that described in the preceeding paragraph. We are interested in investigating more fully the relationship between the two platinum oxidation states, II and IV. Questions that we wish to answer include: What species are capable of oxidizing Pt(II) complexes to Pt(IV); what species are capable of reducing Pt(IV) to Pt(II). What biologically relevant reducing agents are capable of reducing Pt(IV) to Pt(II)? Is the same distribution of stereoisomers produced at both Pt(II) and Pt(IV) centers during the conversion of a coordinated nitrile to an iminoether or is the distribution different for the two oxidation states? Multinuclear NMR is used extensively as a characterization tool for all the chemistry described above.
S.G. Ward, R.C. Taylor, P. Kopf-Maier, H. Kopf, J.Balzarini, E. DeClercq, "Assessment of the In Vitro Broad-spectrum Antiviral Activity of Some Selected Antitumor Metallocene and Metallocenium Complexes," Applied Organometallic Chemistry, 3, 491-497 (1989)
R.C. Taylor and S.G. Ward,"The Antiviral Activity of Some Selected Inorganic and Organometallic Complexes-Possible New Chemotherapeutic Strategies," in: Lectures in Bioinorganic Chemistry, M. Nicolini and L. Sindellari, Cortina International Press, Verona, 63-90, (1991).
S. Kodali, M. Burkley, K. Nag, R.C. Taylor, and V.K. Moudgil, "Taxol and Cisplatin Inhibit Proliferation of T47D Human Breast Cancer Cells,"Biochem. Biophys. Res. Comm., 202, 1413 (1994).
Y. Razskazovskii, S.G. Swarts, J.M. Falcone, C. Taylor, M.D. Sevilla, "Competitive Electron Scavenging by Chemically Modified Pyrimidine Bases in Bromine-Doped DNA: Relative Efficiencies and Relevance to Intrastrand Electron Migration Distances,"J. Phys. Chem., 101, 1460-1467 (1997).
A.L. Sanchez, H. Khattree, R.C. Taylor, and V.K. Moudgil, "Effect(s) of chemotherapeutic agent, Cisplatin, on the regulation of tumor suppressor protein p53 in human breast cancer cells," Meeting of the Minds: Journal of Undergraduate Research, vol.1, 133 (1998).