Title: Assistant Professor Chemistry and Biochemistry
Office: 291 Science and Engineering Building
Martic Group Website
M.Sc. Chemistry, McMaster University (2003-2005)
Ph.D. Chemistry, Queen’s University (2005-2009)
Postdoctoral fellow, Western University (2009-2011)
Postdoctoral fellow, University of Toronto Scarborough (2009-2012)
Research in Martic Lab is on the interface of chemistry and biology, and focuses on designing functional bioconjugates for understanding the biological processes at the fundamental level. Current research projects combine organic synthesis and analytical chemistry for probing the biomolecular interactions in solution and on surfaces. The optical spectroscopy and electrochemistry are typically used to study the key interactions between peptides, proteins, and DNA. The biological targets of interests are: 1) amyloid peptides and tau proteins in Alzheimer’s disease, 2) biologically relevant metal ions (Ca(II), Zn(II) etc.), and 3) DNA damage. Our interdisciplinary research program combines the organic synthesis, analytical chemistry and surface modifications towards the development of new functional biomolecules as sensing probes in chemical biology.
The current research themes:
- Peptide bioconjugate mimics for probing neurodegenerative diseases
- Fluorescent peptide-based materials
- Designer peptides for metal ion detection and screening
- DNA conjugates for monitoring oxidative damage
- Electrochemical assays for probing protein folding and aggregation
We are currently looking for highly motivated undergraduate and graduate students to join our research team. If you are interested please contact Dr. Martic for further information.
Martic, S., Gabriel, M., Turowec, J., Litchfield, D. W., Kraatz, H.-B. Versatile strategy for biochemical, electrochemical and immunoarray detection of protein phosphorylations, J. Am. Chem. Soc., 2012, ASAP.
Beheshti, S., Martic, S., Kraatz, H.-B. Hierarchical organization of ferrocene peptides. Chem. Eur. J. 2012, 18, 9099-9105.
Ramsaywack, S., Martic, S., Milton, S., Gates, L., Grant, A. S., Labib, M., Decken, A., Kraatz, H.-B. Synthesis and surface investigations of N-substituted-2,5-dithio-7-azabicyclo[2.2.1]heptanes on gold surfaces. J. Phys. Chem. C 2012, 116, 7886-7896.
Martic, S., Beheshti, S., Rains, M., Kraatz, H.-B. Electrochemical investigations into Tau protein phosphorylations. Analyst 2012, 137, 2042-2046.
Martic, S., Tackenburg, S., Bilokin, Y., Golub, A., Bdzhola, V., Yarmoluk, S., Kraatz, H.-B. Electrochemical screening of the indole/quinolone-derivatives as potential casein kinase inhibitors. Anal. Biochem. 2012, 421, 617-621.
Beheshti, S., Martic, S., Kraatz, H.-B. Electrochemical signal-on reporter for amyloid aggregates, ChemPhysChem 2012, 13, 542-548.
Martic, S., Labib, M., Kraatz, H.-B. On chip electrochemical detection of sarcoma protein kinase and HIV-1 reverse transcriptase. Talanta 2011, 85, 2430-2436.
Martic, S., Rains, M. K., Freeman, D., Kraatz, H.-B. Use of 5’-g-ferrocenyl adenosine triphosphate (Fc-ATP) bioconjugates having poly(ethyleneglycol) spacers in Kinase-Catalyzed phosphorylations. Bioconjugate Chem. 2011, 22, 1663-1672.
Labib, M., Martic, S., Shipman, P. O., Kraatz, H.-B. Electrochemical analysis of HIV-1 reverse transcriptase serum level: exploiting protein binding to a functionalized nanostructured surface. Talanta 2011, 85, 770-774.
Martic, S., Labib, M., Kraatz, H. B. Electrochemical investigations of sarcoma-related protein kinase inhibition. Electrochim. Acta2011, 56, 10676-10682.
Labib, M., Shipman, P. O., Martic, S., Kraatz, H.-B. A bioorganometallic approach for the rapid electrochemical analysis of HIV-1 reverse transcriptase in human serum. Electrochim. Acta 2011, 56, 5122-5128.
Martic, S., Labib, M., Shipman, P. O., Kraatz, H.-B. Ferrocene-peptido conjugates: From synthesis to sensory applications.Dalton Trans. 2011, 40, 7264-7290.
Martic, S., Labib, M., Freeman, D., Kraatz, H.-B. Probing the role of the linker in Fc-ATP conjugates: monitoring protein kinase-catalyzed phosphorylations electrochemically. Chem. Eur. J. 2011, 17, 6744-6752.
Labib M., Shipman, P. O., Martic, S., Kraatz, H.-B. Toward an early diagnosis of HIV infection: an electrochemical approach for detection of HIV-1 reverse transcriptase enzyme. Analyst, 2011, 136, 708-715.
Martic, S., Labib, M., Kraatz, H.-B. Enzymatically modified peptide surfaces: towards general electrochemical sensor platform for protein kinase catalyzed phosphorylations. Analyst, 2011, 136, 107-112.
Hanif, M., Henke, H., Meier, S. M., Martic, S., Labib, M., Kandioller, W., Jakupec, M. A., Arion, V. B., Kraatz, H.-B., Keppler, B. K., Hartinger, C. G. The reactivity to biomolecules as anticancer activity determining parameters of M(II)-arene complexes of 3-hydroxy-2(1H>)-pyridones. Inorg. Chem. 2010, 49, 7953-7963.
Martic, S., Wu, G., Wang, S. Interactions of cytidine with N2-functionalized guanosine and cytidine-cytidine exchange involving a GC pair-NMR and fluorescence spectroscopic study. Can. J. Chem. 2009, 88, 524-532.
Martic, S., Wu, G., Wang, S. N2-Functionalized blue luminescent guanosines by 2,2’-dipyridylamino and 2-(2’-Pyridyl)benzimidazolyl chelate groups and their interactions with Zn(II) ions. Inorg. Chem. 2008, 47, 8315-8323.
Rao, Y.-L., Amarne, H., Zhao, S.-B., McCormick, T., Martic, S., Sun, Y., Wang, R.-Y., Wang, S. Reversible intramolecular C-C bond formation/breaking and color switching mediated by a N,C,-chelate in (2-ph-py)BMes2 and (5-BMes2-2-ph-py)BMes2. J. Am. Chem. Soc. 2008, 130, 12898-12900.
Martic, S., Liu, X., Wang, S., Wu, G. Self-assembly of N2-modified guanosine derivatives: formation of discrete G-octamers.Chem. Eur. J. 2008, 14, 1196-1204.
Martic, S., Brennan, J., Ackloo, S., Nagy, N., Brook, M.A. Towards the development of a covalently tethered MALDI system: a study of allyl-modified MALDI matrices. Can. J. Chem. 2007, 85, 66-76.