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Mi Hye Song

Mi Hye Song
Assistant Professor, Ph.D.
344 DHE
(248) 370-4494
Lab Location: 333 DHE
Lab phone: (248) 370-3569
FAX: (248) 370-4225

Degree: Ph.D., University of California at Berkeley, 2000

Courses:

·         BIO 325 Biochemistry I

·         BIO 326 Biochemistry I Lab


 Centrosome regulation

Centrosomes are the primary microtubule-organizing centers (MTOCs) in animal cells, which play an instrumental role in cell polarity, intracellular transport, cell motility, and bipolar spindle assembly. While not absolutely required for mitosis, centrosomes normally play a key role in establishing bipolar spindles. Thus, precise regulation of centrosome assembly is crucial for the correct segregation of chromosomes as cells divide. Genomic instability, a feature of many cancers, is often associated with aberrant centrosomes. Recent studies demonstrated that extra centrosomes alone suffice to promote genomic instability via erroneous attachment of chromosome to microtubules, which is mediated by multipolar intermediates. An understanding of the molecular and genetic mechanisms of centrosome assembly should aid our knowledge of human diseases in which this process goes awry. Despite dramatic recent progress, we are still far from a full comprehension of centrosome biogenesis and its link to the cell cycle. Our laboratory is applying a combination of biochemistry, cell biology, genetics, proteomics and quantitative imaging to the study of centrosome biology in the nematode Caenorhabditis elegans model.

Selected Publications:

Song MH, Liu Y, Anderson DE, Jahng WJ., and O’Connell KF (2011) Protein Phosphatase 2A-SUR-6/B55 Regulates centriole duplication by controlling the levels of centriole assembly factors ZYG-1 and SAS-5 in C.elegans. Developmental Cell 20: 563-571. 


Peters N, Perez D, Song MH, Liu Y, Müller-Reichert T, Caron C, Kemphues K, and O'Connell KF (2010) Control of Mitotic and Meiotic Centriole Duplication by the Plk4-Related Kinase ZYG-1.Journal of Cell Science 123: 795-805.


Song MH, Aravind L, Müller-Reichert T, and O'Connell KF (2008) The Conserved Protein SZY-20 Opposes the Plk4-Related Kinase ZYG-1 to Limit Centrosome Size. Developmental Cell 15: 901-912.


Song MH, Miliaras NB, Peel N, and O’Connell KF (2008) Centrioles: Some Self-Assembly Required. Current Opinions in Cell Biology 20: 688-693. 


Kemp C, Song MH, Addepalli MK, Hunter G and O’Connell K (2007) Suppressors of zyg-1 define regulators of centrosome duplication and nuclear association in C. elegans. Genetics 176: 95-113. (Selected for Issue Highlights).


Rivera AS, Gonsalves FC, Song MH, Norris BJ and Weisblat DA (2005) Characterization of Notch-class gene expression in segmentation stem cells and segment founder cells in Helobdella robusta (Lophotrochozoa; Annelida; Clitellata; Hirudinida; Glossiphoniidae).Evolution and  Development 7: 588-599.


Song MH, Brown NL and Kuwada JY (2004) The cfy mutation disrupts cell divisions in a stage-dependent manner in zebrafish embryos. Developmental Biology 276: 194-206.


Song MH, Huang F, Gonsalves FC and Weisblat DA (2004) Cell cycle-dependent expression of a hairy and Enhancer of split (hes) homolog during cleavage and segmentation in the leech embryos. Developmental Biology 269: 183-195.


Song MH, Huang F, Chang G and Weisblat DA (2002) Expression and function of an even-skipped homolog in the leech Helobdella robusta. Development 129: 3681-3692. 


Hagen TM, Ingersoll RT, Wehr CM, Lykkesfeldt J, Vinarsky V, Bartholomew JC, Song MH, and Ames BN (1998) Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proceedings of the National Academy of Sciences USA 95: 9562-6.