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Virinder K. Moudgil

Virinder K. Moudgil
Professor Emeritus, Ph.D
moudgil@oakland.edu

 

Positions

  • Biological Sciences Chair, 1994 - 2001
  • Senior Vice President for Academic Affairs and Provost, 2001-2012

Degree: Ph.D. Banaras Hindu University, 1972

Research: Molecular Mechanisms of Steroid Hormone Action in Normal and Cancer Cells

Dr. Moudgil investigated the molecular mechanism of steroid hormone action for more than three decades. Early work in his laboratory centered on examining structural and functional alterations in progesterone and glucocorticoid receptor proteins induced by phosphorylation, and hormonal and antihormonal ligands. His lab's most recent activity examined hormonal regulation of tumor suppressor proteins, p53 and retinoblastoma, in human breast cancer cells.

Selected Publications:

Moudgil, V.K. (2014) Perspectives on Medical Education in India – A Guest Editorial. MGM Journal of Medical Sciences, 1, vii-viii.

Siebert, A.E., Sanchez, A.L., Dinda, S., and Moudgil, V.K. (2011) Effects of estrogen metabolite 2-methoxyestradiol on tumor suppressor protein p53 and proliferation of breast cancer cells.Systems Biology in Reproductive Medicine 57, 279-287.

Dinda, S., Sanchez, A., and Moudgil, V. K. (2010) Effects of LY117018 (a SERM analog of raloxifene) on tumor suppressor proteins and proliferation of breast cancer cells, Hormone Molecular Biology and Clinical Investigation 2, 211-217.

Maxwell, M.S., Goslin, B.R., Gellish, R.E., Hightower, K.R., Olson, R.E., Moudgil, V.K. and Russi, G.D. (2008) Metabolic Syndrome Status changes with Fitness level Change: A Retrospective Analysis. Metabolic Syndrome and Related Disorders 6:8-14.

Yih, T.C., and Moudgil V. K. (2007) Nanotechnology comes of age to trigger the third industrial revolution. Nanomedicine: Nanotechnology, Biology and Medicine 3:245.

Moudgil, V.K. (2007) An Academic Journey. The Oakland Journal 13:12-19.

Gellish, R.L., Goslin, B.R., Olson, R.E., McDonald A., Russi, G.D. and Moudgil, V.K. (2007) Longitudinal Modeling of the Relationship between Age and Maximal heart rate. Medicine & Science in Sports & Exercise 39: 822-829.

Hightower, K.R., Olson, R.E., Gellish, R.L., Russi, G.D., Goslin, B.R. and Moudgil, V.K. (2007) Reversal of Metabolic Syndrome Characteristics. Metabolic Syndrome and Related Disorders5:69-76.

Dinda, S., Sanchez, A. and Moudgil V. K (2002) Estrogen-like effects of thyroid hormone on the regulation of tumor suppressor proteins, p53, retinoblastoma in breast cancer cells Oncogene21:761-768.

Alban, P., Hurd, C., Dinda, D., Khattree, N. and Moudgil, V.K (2001) Differential regulation of retinoblastoma protein by hormonal and anti-hormonal agents in T47D breast cancer cells Journal of Steroid Biochemistry and Molecular Biology 77:135-141.

Moudgil, V.K, Dinda, S., Khattree, N., Jhanwar, S., Alban, P. and Hurd, C. Hormonal regulation of tumor suppressor proteins in breast cancer cells (2001) Journal of Steroid Biochemistry and Molecular Biology 76:105-117.

Hurd, C., Dinda, S. and Moudgil, V.K. 1999. Estrogen-dependent and Independent Activation of the P1 Promotor of the p53 gene in Transiently Transfected Breast Cancer Cells. Oncogene18:1067-1072.

Hurd, C., Nag, K., Khattree, N., Alban, P., Dinda, S. and Moudgil, V.K. 1999. Agonist and antagonist-induced qualitative and quantitative alterations of progesterone receptor from breast cancer cells. Molecular and Cellular Biochemistry 199:49-56.

Hurd, C. and Moudgil, V.K. 1998. Steroid hormone receptor families. In: Handbook of Physiology, Michael Conn, Editor, Oxford University Press, Publishers. p. 383-411.

Dinda, S., Kodali, S., Sevilla, L., Burkley, M., Hurd, C., and Moudgil,V.K. 1997. Influence of inhibitors on the proliferation of T47D human breast cancer cells: alterations in progesterone receptor and p53 tumor suppressor protein. Molecular and Cellular Biochemistry 175:81-89.

Hurd, C., Khattree, N., Dinda, S., Alban, P., and Moudgil, V.K., 1997.Regulation of tumor suppressor proteins, p53, and retinoblastoma by estrogen and antiestrogens in breast cancer cells.Oncogene 15:991-995.

Hurd, C., Khattree, N., Alban, P., Nag, K., Jhanwar, S.C., Dinda, S. and Moudgil, V.K. 1995. Hormonal regulation of the p53 tumor suppressor protein in T47D human breast carcinoma cell line.Journal of Biological Chemistry 270:28507-28510.

Moudgil, V.K., 1994. Steroid/Nuclear Receptor Superfamily: Recent advances and relation to health and disease. In: Steroid Hormone Receptors: Basic and Clinical Aspects (V.K. Moudgil, Ed.), pp 3-44, Birkhauser Boston, Publishers.