Associate Professor, Ph.D.
Lab Location: 302A SEB, 304 SEB
Lab Phone: (248) 370-4903
- BIO 111 Biology I
- BIO 423/523 Immunology
Immune system protects the host against viral infections by inducing a protective immune response comprising of both innate and adaptive immune cell types. These immune cell types in response to microbial invasion secrete both pro-and anti-inflammatory molecules that helps in the resolution of viral infection. However, if the immune response gets dys-regulated, it may cause more harm than benefit to the host tissues. Thus, the body needs to have an array of immunosuppressive mechanisms that will inhibit the exaggeration of immune response and minimize collateral tissue damage. The research program in Dr. Suvas Lab is focused to understand these immunosuppressive events and their role in controlling virus induced chronic inflammation. We are also interested to see age-related changes in immune-suppression and their influence on immunological responses to emerging and latent viral infection. We believe the knowledge gained from these studies will help in the design of more effective anti-inflammatory therapies and better protective vaccines for elderly individuals.
Channappanavar, R., Twardy, B.S., Suvas, S. (2012) Blocking of PDL-1 interaction enhances primary and secondary CD8 T cell response to herpes simplex virus-1 infection. PLoS ONE 7: e39757, epub July 12, 2012.
Twardy, B.S., Channappanavar, R., Suvas, S. (2011) Substance P in the corneal stroma regulated the severity of herpetic stromal keratitis lesions. Investigative Ophthalmology and Visual Science 52: 8604-8613.
Channappanavar, R., Twardy, B.S., Krishna, P., Suvas, S. (2009) Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells. Mechanisms of Aging and Development 130: 709-712.