Degree: Ph.D., University of Toronto, 2004

Courses:

• BIO 513, Advanced Topics/Cell Physiology

The Role of Stem Cells in Cancer.

Many cancers initiate from specific cancer stem/initiating cells (CSCs). While the field of CSCs is under considerable investigation, Dr. Madlambayan’s research utilizes a more global approach to define the integrated roles of different stem and progenitor cell populations in cancer initiation, progression and relapse. Dr. Madlambayan’s work has shown that bone marrow-derived stem cells including blood stem cells play a role in the growth of some cancers (lung and pancreatic) but not others (melanoma). He has also found that endothelial progenitor cells play an important role in the progression of blood related cancers. Dr. Madlambayan is also involved in discovering why regenerative microenvironments (i.e. limbs and tails) resist cancer growth using a salamander/axolotl animal model (Ambystoma Mexicanum). The overall goal of his research is to apply these findings towards developing clinically relevant drugs and drug delivery strategies to treat these diseases.

Madlambayan, G.J., Meacham, A., Hosaka, K., Mir, S., Jorgensen, M., Scott, E.W., Siemann, D.W., Cogle, C.R. Leukemia regression by vascular disruption and anti-angiogenic therapy, Blood, 116:1539-1547, 2010

Madlambayan, G.J., Butler, J., Hosaka, K., Jorgensen, M., Fu, D., Guthrie, S.M., Shenoy, A.K., Brank, A., Russel, K.J., Otero, J., Siemann, D.W., Scott, E.W. and Cogle, C.R. Bone marrow stem and progenitor cell contribution to neovasculogenesis is dependent on model system with SDF-1 as a permissive trigger, Blood, 114:4310-4319, 2009

Madlambayan, G.J., Kim, M. (co-first authors), Rahman, M.M., Smallwood, S.E., Meachem, A., Hosaka, K., Scott E.W., Cogle, C.R. and McFaden, G. Myxoma virus targets primary human leukemic stem and progenitor cells while sparing normal hematopoietic stem and progenitor cells, Leukemia, 23:2313-2317, 2009

Madlambayan, G.J., Rogers, I., Purpura, K.P., Ito, C., Yu, M., Kirouac, D.C., Casper, R.F., and Zandstra, P.W. Clinically relevant expansion of hematopoietic stem cells with conserved function in a single-use, closed-system bioprocess, Biol Blood Marrow Transplant, 12:1020-1030, 2006

Madlambayan G.J., Rogers, I., Kirouac, D.C., Yamanaka, N., Mazurier, F., Doedens, M., Casper, R.F., Dick, J.E. and Zandstra, P.W. Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion, Experimental Hematology, 33:1229-1239, 2005