Associate Professor, Ph.D.
Lab Location: 316 SEB
Lab Phone: (248) 370-4904
- BIO 319 General Microbiology
- BIO 325 Biochemistry I
Research: Biometal homeostasis
homeostasis is critical, and imbalances in their concentrations or metabolism
have important consequences in human pathologies. Her lab explores the
biological roles and the mechanisms of action of two important biometals: arsenic and selenium. The aim is to elucidate
the molecular bases for these important biometals’ function in two animal
models: zebrafish and mouse models. Since membrane transport is the rate-limiting
step for cellular availability, the overall cellular function of these biometals is determined by
membrane transporters. Currently, the lab is identifying these biometal transporters
and studying their transport mechanism. The future goal is to better understand
beneficial or adverse effects of arsenic and selenium and to improve strategies
for future clinical applications.
Jiang, X., McDermott, J.R., Ajees, A.A., Rosen, B.P., Liu, Z. (2012) Trivalents arsenicals and glucose use different translocation pathways in
mammalian GLUT1. Metallomics 2:
Hamdi, M., Yoshinaga, M., Packianathan, C., Qin, J. Hallauer, J., McDermott, J.R., Yang, H.C., Tsai, K.J., Liu, Z. (2012) Identification of an S-adenosylmethionine (SAM) dependent arsenic methyltransferase in Danio rerio. Toxicology and Applied Pharmacology 262: 185-193.
Beene, L.C., Hallauer,
J., Yoshinaga, M., Hamdi, M., Liu, Z. (2011) Pentavalent arsenate transport
by zebrafish phosphate rransporter NaPi-IIb1. Zebrafish 8: 125-31.
McDermott, J.R., Rosen,
B.P., Liu, Z. (2010) Jen1p: A high
affinity selenite transporter in yeast. Mol Biol Cell. 22: 3934-41.
Jiang, X., McDermott, J.R., Ajees, A.A., Rosen,
B.P. and Liu, Z. (2010) Trivalent arsenicals and glucose use
different translocation pathways in mammalian GLUT1. Metallomics. 2:
211-9. (Cover story)
McDermott, J.R., Jiang, X., Beene, L.C., Rosen, B.P., Liu,
Z. (2010) Pentavalent methylated arsenicals are substrates of human AQP9. Biometals
Hamdi, M., Sanchez, M.A.,
Beene, L.C., Liu, Q., Landfear, S.M., Rosen, B.P., Liu, Z. (2009) Arsenic transport by zebrafish
aquaglyceroporins. BMC Mol Biol. 10: 104.