A Mathematical Model for Vibrio Cholera Colonization of the Human Intestine

Abstract

Vibrio Cholera is a strict human pathogen that causes pandemic cholera. It is an old-world pathogen that has re-emerged as anew threat since the early 1990's. V. Cholera colonizes the upper, small intestine where it produces a toxin that leads to the watery diarrhea characterizing the disease. Colonization dynamics of the bacteria are largely unknown. Although a large initial infectious dose is required for infection, data suggest that only a smaller sub-population colonizes a portion  of the small bowel leading to the disease. There are many barriers to colonization in the intestines. In this talk, I will elaborate on the dynamics of V. Cholera infection by describing a mathematical model that governs the colonization process for the bacterial dynamics.

Tuesday, September 13, 2011

3:00– 4:00 P.M.

372 Science and Engineering Building

(Refreshments at 2:30-3:00 PM in the kitchen area adjacent to 368 SEB)