Keith L. Williams, Ph.D.
Associate Professor
Office: 224 Pryale Hall
Phone: 248-370-2308
Fax: 248-370-4612
E-mail: william9@oakland.edu
Major Field
Biopsychology, Physiological Psychology, Psychopharmacology, Behaviorism
Degrees
Ph.D., Biopsychology, University of Michigan, 1998
B.A., Psychology, New Mexico State University, 1994
Research Interests
Alcoholism and drug addiction continue to plague society despite recent progress in the treatment of these problems and the understanding of the underlying biological mechanisms. Research has shown that behavioral and biological factors influence drug consumption. My focus is on bridging the gap between the behavioral and biological components that modulate drug-taking behavior and addiction. My interests include the pharmacological and behavioral mechanisms of drug reinforcement and craving, drug discriminative stimulus properties, hormonal influences on drug self-administration, and contribution of food intake mechanisms on drug consumption.
Publications
Williams KL , Broadbridge CL (2009). Effect of Naltrexone on Ethanol Self-Administration in Rats: Potency Difference Between Intraperitoneal and Subcutaneous Injection. Alcohol 43: 119-126.
Williams KL , Schimmel JS (2008). Effect of Naltrexone During Extinction of Alcohol Reinforced Responding and During Repeated Cue-Conditioned Reinstatement Sessions in a Cue Exposure Style Treatment. Alcohol 42: 553-563.
Williams KL (2007). Development of Naltrexone Supersensitivity During Food-Maintained Responding Enhances Naltrexone’s Ability to Reduce Ethanol-Maintained Responding. Alcoholism: Clinical and Experimental Research 31: 39-47.
Williams KL, Broadbear JH, Woods JH (2004). Non-contingent and Response-contingent Intravenous Ethanol Attenuates the Effect of Naltrexone on Hypothalamic-Pituitary- Adrenal Activity in Rhesus Monkeys. Alcoholism: Clinical and Experimental Research 28: 566-571.
Williams KL, Ko MC, Woods JH (2003). Effect of Opioid Receptor-Selective Antagonists on Hypothalamic-Pituitary-Adrenal Activity in Rhesus Monkeys. Psychoneuroendocrinology 28: 513-528.
Williams KL, Kane EC, Woods JH (2001) Interaction of Morphine and Naltrexone on Oral Ethanol Self-Administration in Rhesus Monkeys. Behavioral Pharmacology 12: 325-333.
Thompson LA, Williams K, L’Esperance P, Cornelius J. (2001) Context-dependent memory under stressful conditions: The case of skydiving. Human Factors 43: 611-619.
Williams KL, Woods JH (2000) A Behavioral Economic Analysis of Concurrent Ethanol- and Water-Reinforced Responding in Different Preference Conditions. Alcoholism: Clinical Experimental Research 24: 980-986.
Williams KL, Woods JH (1999) Naltrexone Reduces Ethanol- and/or Water-Reinforced Responding in Rhesus Monkeys: Effect Depends upon Ethanol Concentration. Alcoholism: Clinical Experimental Research. Alcoholism Clinical Experimental Research 23: 1462-1467.
Williams KL, Pakarinen ED, Woods JH (1999) Quadazocine Decreases Reinforced-Responding for Oral Ethanol, Sucrose, and Phencyclidine: Comparison to Naltrexone Effects. Psychopharmacology 144: 316-322.
Williams KL, Woods JH (1999) Conditioned Effects Produced by Naltrexone Doses that Reduce Ethanol-Reinforced Responding in Rhesus Monkeys. Alcoholism: Clinical Experimental Research 23: 708-715.
Pakarinen ED, Williams KL, Woods JH (1999) Food Restriction and Sex Differences on Concurrent, Oral Ethanol and Water Reinforcers in Juvenile Rhesus Monkeys. Alcohol 17: 35-40.
Williams KL, Woods JH (1998) Oral Ethanol-Reinforced Responding in Rhesus Monkeys: Effects of Opioid Antagonists Selective for the Mu-, Kappa-, or Delta-Receptor. Alcoholism: Clinical Experimental Research 22: 1634-1639.
Williams KL, Winger G, Pakarinen ED, Woods JH (1998) Naltrexone Reduces Ethanol- and Sucrose-Reinforced Responding in Rhesus Monkeys. Psychopharmacology 139: 53-61.