COLLOQUIUM
DEPARTMENT OF MATHEMATICS AND STATISTICS
OAKLAND UNIVERSITY
ROCHESTER, MICHIGAN 48309
Xianggui (Harvey) Qu
Department of Mathematics and Statistics
Oakland University
Rochester, Michigan 48309
Optimal Plate Designs in High Throughput Screening
Abstract
High-throughput
screening (HTS) is a large-scale process that screens hundreds of
thousands to millions of compounds in order to identify potentially
leading candidates rapidly and accurately. There are many
statistically challenging issues in HTS. In this talk, I will focus on the
spatial effect in primary HTS. I will discuss the consequences of
spatial effects in selecting leading compounds and why the current
experimental design fails to eliminate these spatial effects. A new
class of designs will be proposed for elimination of spatial effects.
The new designs have the advantages such as all compounds are
comparable within each microplate in spite of the existence of spatial
effects; the maximum number of compounds in each microplate is
attained, etc. Optimal designs are recommended for HTS experiments
with one and multiple controls.
Thursday, October 22, 2009
3:00 – 4:00 P.M.
372 Science and Engineering Building
(Refreshments at 2:30-3:00 PM in the kitchen area adjacent to 368 SEB)